22 Jul Gut Health and Multiple Sclerosis
Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Inappropriate inflammation of your CNS occurs, and it is thought that a type of white blood cells called T cells causes harm to the myelin sheaths of your nerves. Myelin sheaths provide a protective coating around your nerves.
The exact reason for the development of MS is not known. Gut Health and Multiple Sclerosis are linked. There are links to gut imbalance and the development and progression of MS. It seems that gut dysbiosis or imbalance may lead to dysfunction of your immune cells such as your B and T cells. Also, the cells of the central nervous system make the myelin sheaths and maintain a healthy and balanced state for the nerves cells called Glia cells.
Everyone’s gut microbiome is different and what is considered an optimal type and variety of microbes can vary between individuals. Therefore, a single probiotic strain from a supplement is not recommended to reduce your risk of developing MS. A whole diet approach that includes two daily sources of probiotic-rich foods and beverages and a variety of different plant foods is far superior to the benefit of your health. The sum of health benefits of whole foods far outweighs what one single probiotic supplement could possibly provide to your body.
Most people are not meeting their daily recommended fibre needs. This is a good sign that most people are not including enough fibre rich foods from plant sources. One way you can boost your fibre is through enjoying a delicious pouch of South Australian Gourmet Food Company Fruit Custard with Added Fibre. Each pouch gives your body 10.9g of dietary fibre.
Fibre is vital to keep your gut functioning optimally as well as feeding the good bacteria in your gut to stay healthy and protect your body. 70% of your immune system is in your gut and having a healthy gut microbiome promotes an optimal immune system function and reduces chronic-low-grade inflammation which can lead to many diseases.
Take home message: While the exact reasons for the development of MS is unknown, there appears to be a link between gut health and Multiple Sclerosis. Make sure that your diet is supporting a healthy gut microbiome which in turn will help to protect your CNS from disease.
Reference:
- Noto D, Miyake S. Gut dysbiosis and multiple sclerosis. Clin Immunol. 2020 Mar 10:108380. doi: 10.1016/j.clim.2020.108380. Epub ahead of print. PMID: 32169440.
- Pröbstel AK, Baranzini SE. The Role of the Gut Microbiome in Multiple Sclerosis Risk and Progression: Towards Characterization of the “MS Microbiome”. Neurotherapeutics. 2018 Jan;15(1):126-134. doi: 10.1007/s13311-017-0587-y. PMID: 29147991; PMCID: PMC5794700.
- Ochoa-Repáraz J, Kirby TO, Kasper LH. The Gut Microbiome and Multiple Sclerosis. Cold Spring Harb Perspect Med. 2018 Jun 1;8(6):a029017. doi: 10.1101/cshperspect.a029017. PMID: 29311123; PMCID: PMC5983160.
- Shahi SK, Freedman SN, Mangalam AK. Gut microbiome in multiple sclerosis: The players involved and the roles they play. Gut Microbes. 2017 Nov 2;8(6):607-615. doi: 10.1080/19490976.2017.1349041. Epub 2017 Aug 3. Erratum for: Addendum to: Chen J, , Chia N, , Kalari KR, , Yao JZ, , Novotna M, , Soldan MM, et al. Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Sci Rep 2016; 6:28484. PMID: 28696139; PMCID: PMC5730390.
- Adamczyk-Sowa M, Medrek A, Madej P, Michlicka W, Dobrakowski P. Does the Gut Microbiota Influence Immunity and Inflammation in Multiple Sclerosis Pathophysiology? J Immunol Res. 2017;2017:7904821. doi: 10.1155/2017/7904821. Epub 2017 Feb 20. PMID: 28316999; PMCID: PMC5337874.
- Anderson G, Rodriguez M, Reiter RJ. Multiple Sclerosis: Melatonin, Orexin, and Ceramide Interact with Platelet Activation Coagulation Factors and Gut-Microbiome-Derived Butyrate in the Circadian Dysregulation of Mitochondria in Glia and Immune Cells. Int J Mol Sci. 2019 Nov 5;20(21):5500. doi: 10.3390/ijms20215500. PMID: 31694154; PMCID: PMC6862663.